甘草次酸钠

2020-10-29

甘草次酸钠

sodium glycyrrhetinic acid(7)
sodium glycyrrhetinic acid plaster(2)
glycyrrhetae(0)


  sodium glycyrrhetinic acid
     The protective effect of sodium glycyrrhetinic acid(SGA) on injured myocardial cells from neonate rats was investigated.
     观察甘草次酸钠(SGA)对培养乳鼠心肌细胞损伤的保护作用。
短句来源
     The Effect of Sodium Glycyrrhetinic Acid on the Experimental Myocardial Infarction in Rabbits
     甘草次酸钠对兔实验性心肌梗塞的影响
短句来源
     Antiinflammatory and immune regulating effect of sodium glycyrrhetinic acid by oral administration in mice and rats
     甘草次酸钠口服给药的抗炎及免疫调节作用
短句来源
     Effect of azone on the transdermal absorption of sodium glycyrrhetinic acid plaster
     氮酮对甘草次酸钠透皮吸收的影响
短句来源
     It was demonstrated that the plaster containing 0.5% azone,1.0% azone and 2.0% azone could remarkble increase the skin penetration of the Sodium glycyrrhetinic acid plaster.
     含不同浓度氮酮的甘草次酸钠贴剂间,其透皮吸收无显著性差异(P>0.05);
短句来源
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  sodium glycyrrhetinic acid plaster
     Effect of azone on the transdermal absorption of sodium glycyrrhetinic acid plaster
     氮酮对甘草次酸钠透皮吸收的影响
短句来源
     It was demonstrated that the plaster containing 0.5% azone,1.0% azone and 2.0% azone could remarkble increase the skin penetration of the Sodium glycyrrhetinic acid plaster.
     含不同浓度氮酮的甘草次酸钠贴剂间,其透皮吸收无显著性差异(P>0.05);
短句来源
  “甘草次酸钠”译为未确定词的双语例句
     The inhibition rates of GC-Na, ip 10 mg/kg×10d for S_(180) and Hep in mice were 53.13%(P<0.05) and 40.10%(P<0.05).
     甘草次酸钠腹腔给药对小鼠S180、HepS具有不同程度的抑制作用,在10mg/kg时,抑制率分别为53.13%和40.10%(P值<0.05)。
短句来源
     Effect of Sodtum 18β-Glycyrrhetae on Experimental Arrhythmia
     18β-甘草次酸钠对实验性心律失常的影响
短句来源
     Effect of 18β-Sodium Glycyrrhetate on Mice Peritoneal Macrophages' Uptake of OX-LDL and Mechanism Study
     18β-甘草次酸钠对小鼠腹腔巨噬细胞摄取氧化型低密度脂蛋白的影响及其作用机制研究
短句来源
     EFFECTS OF 18β-SODIUM GLYCYRREHETIC ACID (SGA)ON INFLAMMATION AND IMMUNE FUNCTION
     18β—甘草次酸钠对炎症和免疫功能的影响
短句来源
     Results Chemical reactions to calcium carbonate and alkaloids in Corydalis bulbosa were positive.

 


Sodium glycyrrhetinate (GC-Na) was studied in the transplanted mouse tumors. The experiments showed. that S_(180) and Hep were significantly in- hibited by GC-Na. The inhibition rates of GC-Na, ip 10 mg/kg×10d for S_(180) and Hep in mice were 53.13%(P<0.05) and 40.10%(P<0.05). Moreover, the inhibition rate of mitotic indices of hepatoma cells were moderately in- creased affter ip administration of GC-Na with 36.81% for 1h and 43.15% after 24h (P<0.05). Electron microscopic observation: Vacuolations were found... 显示全部
本文观察了甘草次酸钠对小鼠移植性肿瘤的抑制作用,并在此基础上观察了其对瘤细胞分裂指数和超微结构的影响,以及对抗肿瘤药物作用的影响。甘草次酸钠腹腔给药对小鼠S180、HepS具有不同程度的抑制作用,在10mg/kg时,抑制率分别为53.13%和40.10%(P值<0.05)。该药对HepA细胞分裂指数有抑制作用,24小时时,分裂指数抑制率为43.15%。电镜观察发现;使HepA细胞线粒体空泡变性,甚至界膜破损,细胞质中糖元颗粒减少,粗面内质网腔缩小,核染色质变细疏,膜完整性示踪剂镧颗粒进入胞质和核内。该药与抗肿瘤药物合用因不同药物和给药时间相异其增效作用亦不同,以ip喜树碱5分钟后投与本药为佳。此外本药对喜树碱引起的白细胞减少亦有保护作用。
The effect of SGA on tolerance toward hypoxia are studied. When intraperitoneal injection of 14mg/kg and 21mg/kg of SGA, the hypoxic survial time of the mice under 630mmHg and low atmospheric pressure, histanoxia induced by, KCN or NANO_2 and cerebral histanoxia caused by a carotis communis being ligatured were prolonged significantly. The venae dorsalis linguae injection of 10.5mg/kg SGA produced noticeable influence on ECG of anestheti- zed rats. The acute LD_(50) of SGA in miceare 406±79mg/kg administered... 显示全部
甘草次酸钠ip,14mg/kg,21mg/kg能明显延长小鼠在常压及减压条件下的存活时间。增强氰化钾、亚硝酸钠引起组织缺氧和结扎颈总动脉造成脑循环障碍性缺氧的耐受力。能明显对抗大鼠因垂体后叶素所致急性心肌缺血心电图的变化。
The pharmacological effects of SGA on dogs, mice and rats were studied. The experimental results showed that SGA significantly inhibited capillary permeably induced by phlogistic stimulants and exudation induced by croton oil. Both the edema of the hind paw in the rats by means of egg-white and the granuloma formation in the rats' shoulders by round paper were inhibited. It's of an equal antiinflam-matory effect as hydrocortisone. Intraperitoneal injection of SGA increased in the ability of macrophage phagocytosis... 显示全部
甘草次酸钠是中药甘草主要成分甘草次酸的盐类。对多种动物的急慢性炎症模型均有明显的抑制作用,其作用强度与氢化可的松相近似。SGA对机体非特异性细胞免疫功能也有增强作用。本品毒性较小。

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